(transitive, figurative) To cause (something) not to be in harmony or to be poorly adjusted.
1654, Thomas Jackson, A Treatise of the Primaeval Estate of the First Man, Section 2, Chapter 13, in An Exact Collection of the Works of Doctor Jackson, London: Timothy Garthwait, p. 3037,
But by eating of the forbidden fruit, and losse of Paradise, his very substance was corrupted and deprived of Life Spiritual: and all his Powers or Faculties not only corrupted, but distuned.
1802, Charles Lamb, John Woodvil, Act IV, in The Works of Charles Lamb, London: C. and J. Ollier, 1818, Volume 1, p. 146,
O most distuned, and distempered world, where sons talk their aged fathers into their graves!