2010, Susan Klugman and Susan J. Gross, “Ashkenazi Jewish Screening in the Twenty-first Century,” in Anthony R. Gregg and Joe Leigh Simpson (eds.), Genetic Screening and Counseling, an issue of Obstetrics and Gynecology Clinics of North America, March 2010, Volume 37, No. 1, p. 40,
TSD is a neurodegenerative disorder that presents in the first year of life and is fatal in early childhood. […] Infants are classically macrocephalic because of storage material accumulation in the brain and have the characteristic cherry red spot on their macula.
(geography) Characterized by a disproportionate concentration of population and activities in a single centre, to the detriment of other areas.