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The report warns that the parasite Plasmodium falciparum — which causes the most lethal form of human malaria — is becoming resistant to the first-choice drug, DHA-piperaquine, in parts of Southeast Asia, with patients seeing a failure rate of 50 percent or more.
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The report says urgent action is now needed to eliminate falciparum malaria from the region — otherwise the resistant strains of the parasite could further spread to other parts of Asia and Africa, potentially causing global health emergency.
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This week, scientists at the Johns Hopkins Malaria Research Institute announced that they have identified a sugar in mosquitoes that the malaria-causing parasite [Plasmodium falciparum] needs. The sugar is essential for the parasite's movement within the midgut section of the mosquito's body.
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There are four types of malaria parasite that typically infect people. The most common and deadly is Plasmodium falciparum, which goes through a number of life-cycle stages during which the parasite evolves into a different form.
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Researchers reporting in the journal The Lancet Infectious Diseases found that a lineage of the P. falciparum parasite, which causes the most dangerous form of malaria, is now becoming resistant to the most effective malaria drug, and the resistance is spreading.
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Researchers at the Center for Infectious Disease Research at the University of Washington in Seattle, in conjunction with the Fred Hutchison Cancer Research Center, have developed a vaccine that uses the entire malaria-causing parasite — called P. falciparum — to stimulate a protective immune response.
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