(slang, mildly vulgar) Beset with unfortunate circumstances that seem difficult or impossible to overcome; in imminent danger.
They found out about our betrayal, so now we're screwed.
(slang, British, dated) Intoxicated.
verb
simple past and past participle of screw
He screwed the boards together tightly.
I got screwed at the swap meet yesterday.
1641, Richard Chambers (merchant), quoted in Hannis Taylor, The Origin and Growth of the English Constitution: An Historical Treatise, Part II: The After-Growth of the Constitution, H.O. Houghton & Company (1889), p. 274,
[…] merchants are in no part of the world so screwed as in England. In Turkey, they have more encouragement.